HEPATITIS & LIVER DISEASES

Biography

I, Hamza Waqar Bhatti , am a young aspirant researcher having a passion for medical sciences since childhood. I am the postion holder of my class and the chief co ordinator of Rawalian Student Research Society. Research has always been very attractive to me; to find more of what has already been found.i hope to become a charismatic and most importantly a safe doctor one day.       
 

Abstract

BACKGROUND :

Renal dysfunction is a common complication in patients with decompensated liver cirrhosis. Acute kidney injury occurs approximately in 19% of hospitalized patients with cirrhosis.

OBJECTIVE

To assess factors associated with Renal dysfunction in HCV cirrhosis, correlate renal parameters with Child Pugh score and calculate a cut off value of Child Pugh score to determine renal dysfunction.

MATERIALS AND METHODS:

This cross sectional study included 70 cases of liver cirrhosis secondary to HCV from a period of Jan ‘18-June ’18 at CMH Multan.. Child Pugh score was determined and lab reports were taken on the same day. Patients were divided into two groups on the basis renal function. eGFR was calculated. Data was analyzed using SPSS v23.0. Chi square, Kruskal Wallis test and Pearson coefficient of correlation was applied.

RESULTS:

Patients with ascites and encephalopathy are prone to develop renal dysfunction as well (P=0.000, OR 32.6; P= 0.012, OR=3.5 respectively). Creatinine, urea positively correlates with CP score ( P= 0.000, P=0.000). ). eGFR negatively correlates with CP score (r=-0.359, P=0.002) Area under ROC curve was 0.730 (P = 0.001) for 95% confidence interval. Cut off value of 8.5 shows 80% sensitivity, and 60% specificity.

CONCLUSION:

Patients with Child Pugh B and C have renal dysfunction as compared to Child Pugh A. A cut off value of CP score 8.5 is highly sensitive to detect renal dysfunction in HCV related liver cirrhosis.